ASSOCIATION BETWEEN TWENTY SERUM MIRNAS AND CLINICOPATHOLOGICAL VARIABLES IN PATIENTS WITH BREAST CANCER

Determining that miRNAs play a role in breast cancer pathogenesis suggests it may be useful the diagnosis and treatment of cancer. In this study, 39 patients with invasive were diagnosed serum levels 20 miRNAs(miR-105, miR-21, miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375, miR-34a, miR-133a, miR-155, miR-139-5p, miR-143, miR-145, miR-365, miR-299-5p, miR-411, miR-452, miR-17) analyzed during after treatment. analysis results, is detected miR-200c(p=0.030), miR-375(p=0.045), miR-34a(p=0.042) significantly higher local advanced/metastatic group. Serum level miR-141(p=0.062) was lower positive lymph node involvement, whereas miR-133a(p=0.037) same patient MiR-105(p=0.015), miR-203(p=0.015), miR-375(p=0.033), miR-145(p=0.025) progesterone receptor negative group, likewise miR-105(p=0.053) high estrogen The miR-375 miR-133a noticeable human epidermal growth factor receptor-2 patients(p=0.037 p=0.014, respectively). MiR-143(p=0.009) miR-145(p=0.017) observed to group ki-67 index>20%. It found 2 miRNAs(miR-133a(p=0.018) miR-139-5p(p=0.004)) luminal B which separated by molecular subgroups. Nine evaluated(miR-105(p=0.0001), miR-21(p=0.001), miR-141(p=0.041), miR-200a(p=0.003), miR-200b(p=0.0001), miR-200c(p=0.0001), miR-203(p=0.0001), miR-34a(p=0.0001), miR-452(p=0.018)) increased 5 miRNAs(miR-155(p=0.0001), miR-143(p=0.0001), miR-145(p=0.0001), miR-365(p=0.0001), miR-299-5p(p=0.0001)) reduced We think help evaluating follow-up prognosis